Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

• Main Authors: Dasiel O. Borroto-Escuela (Author), David Rodriguez (Author), Wilber Romero-Fernandez (Author), Jon Kapla (Author), Mariama Jaiteh (Author), Anirudh Ranganathan (Author), Tzvetana Lazarova (Author), Kjell Fuxe (Author), Jens Carlsson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allosteric interactions across the A2AR-D2R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinants of A2AR-D2...