Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

• मुख्य लेखकों: Lai Peng (लेखक), Stephanie Piekos (लेखक), Grace L. Guo (लेखक), Xiao-bo Zhong (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver. However, the role of FXR in regulating ontogeny of phase-I drug metabolizing genes is not clear. H...