Noninvasive prenatal testing for fetal trisomy in a mixed risk factors pregnancy population
Objective: This study assesses the performance of noninvasive prenatal testing (NIPT) for fetal aneuploidies in a mixed risk factors pregnancy population. Materials and methods: Data review of 169 pregnant women undergoing prenatal aneuploidy screening in a single tertiary medical center was conduct...
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Elsevier,
2015-04-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_9f700da0c55e4b59adacd2bc8da47675 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Wai-Hou Li |e author |
| 700 | 1 | 0 | |a Peng-Hui Wang |e author |
| 700 | 1 | 0 | |a Chi-Mu Chuang |e author |
| 700 | 1 | 0 | |a Yi-Wen Chang |e author |
| 700 | 1 | 0 | |a Ming-Jie Yang |e author |
| 700 | 1 | 0 | |a Chih-Yao Chen |e author |
| 700 | 1 | 0 | |a Kuan-Chong Chao |e author |
| 700 | 1 | 0 | |a Ming-Shyen Yen |e author |
| 245 | 0 | 0 | |a Noninvasive prenatal testing for fetal trisomy in a mixed risk factors pregnancy population |
| 260 | |b Elsevier, |c 2015-04-01T00:00:00Z. | ||
| 500 | |a 1028-4559 | ||
| 500 | |a 10.1016/j.tjog.2015.02.001 | ||
| 520 | |a Objective: This study assesses the performance of noninvasive prenatal testing (NIPT) for fetal aneuploidies in a mixed risk factors pregnancy population. Materials and methods: Data review of 169 pregnant women undergoing prenatal aneuploidy screening in a single tertiary medical center was conducted. Indications included maternal anxiety, advanced maternal age, abnormal nuchal translucency, and high/moderate risk of first trimester Down syndrome screening. Multifetal pregnancies and patients receiving in vitro fertilization were also enrolled for analysis. Results: A total of 169 patients were enrolled in this study during a time period from July 2012 to June 2014. For patients' ≥ 34 years, anxiety about amniocentesis was the most common reason for patients selecting NIPT for fetal aneuploidy screening, with 107 (88.4%) patients choosing NIPT for this reason. Among the total patient population, two patients showed a positive result from NIPT. One patient displayed 47, XXY, which was confirmed to be a false-positive result. The other patient displayed trisomy 18, which was confirmed by an amniotic cell culture. The sensitivity for NIPT is 100% with the specificity 99.4%. Conclusions: NIPT for fetal aneuploidy in a mixed risk factors pregnancy population showed high accuracy. NIPT applied to the low risk population might reassure the anxious family. | ||
| 546 | |a EN | ||
| 690 | |a Non-invasive prenatal test | ||
| 690 | |a Trisomy | ||
| 690 | |a Down syndrome | ||
| 690 | |a First trimester down screening | ||
| 690 | |a Nuchal translucency | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Taiwanese Journal of Obstetrics & Gynecology, Vol 54, Iss 2, Pp 122-125 (2015) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1028455915000236 | |
| 787 | 0 | |n https://doaj.org/toc/1028-4559 | |
| 856 | 4 | 1 | |u https://doaj.org/article/9f700da0c55e4b59adacd2bc8da47675 |z Connect to this object online. |