Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis

• Hlavní autoři: Sinethemba Yakobi (Autor), Lindiwe Zuma (Autor), Ofentse Pooe (Autor)
• Médium: Kniha
• Vydáno: Hindawi Limited, 2024-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence of flavonoids, namely, rutin, on the structur...