Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis

• Hauptverfasser: Sinethemba Yakobi (Verfasst von), Lindiwe Zuma (Verfasst von), Ofentse Pooe (Verfasst von)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2024-01-01T00:00:00Z.
• Schlagworte: article
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Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence of flavonoids, namely, rutin, on the structur...