Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis

• Auteurs principaux: Sinethemba Yakobi (Auteur), Lindiwe Zuma (Auteur), Ofentse Pooe (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 2024-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence of flavonoids, namely, rutin, on the structur...