Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis

• Main Authors: Sinethemba Yakobi (Author), Lindiwe Zuma (Author), Ofentse Pooe (Author)
• פורמט: ספר
• יצא לאור: Hindawi Limited, 2024-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence of flavonoids, namely, rutin, on the structur...