Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis

• Autori principali: Sinethemba Yakobi (Autore), Lindiwe Zuma (Autore), Ofentse Pooe (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2024-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence of flavonoids, namely, rutin, on the structur...