Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel

• Main Authors: Anne Steins (Author), Eva A. Ebbing (Author), Marcel C. M. Pistorius (Author), Cynthia Waasdorp (Author), Kausilia K. Krishnadath (Author), Jan Paul Medema (Author), Johanna W. Wilmink (Author), Ron A. A. Mathôt (Author), Maarten F. Bijlsma (Author), Hanneke W. M. van Laarhoven (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis is critical to the growth of tumors. Vascularization-targeting agents, with or without cytotoxic drugs, are widely used for the treatment of several solid tumors including esophagogastric adenocarcinoma. However, little is known about the systemic effects of anti-angiogenic therapies an...