Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate
Osteogenesis imperfecta (OI) types VII, VIII and IX, caused by recessive mutations in cartilage-associated protein (CRTAP), prolyl-3-hydroxylase 1 (P3H1) and cyclophilin B (PPIB), respectively, are characterized by the synthesis of overmodified collagen. The genes encode for the components of the en...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2019-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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