Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and...
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Elsevier,
2020-10-01T00:00:00Z.
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| 001 | doaj_9fc2bc4cfa004a55ab0bbada4d5a0d21 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Daiki Masukawa |e author |
| 700 | 1 | 0 | |a Daisuke Nishizawa |e author |
| 700 | 1 | 0 | |a Kaori Kanai |e author |
| 700 | 1 | 0 | |a Satoshi Kitamura |e author |
| 700 | 1 | 0 | |a Yuka Kasahara |e author |
| 700 | 1 | 0 | |a Tatsuo Hashimoto |e author |
| 700 | 1 | 0 | |a Ryo Takahagi |e author |
| 700 | 1 | 0 | |a Junko Hasegawa |e author |
| 700 | 1 | 0 | |a Kyoko Nakayama |e author |
| 700 | 1 | 0 | |a Naomi Sato |e author |
| 700 | 1 | 0 | |a Fumihiko Tanioka |e author |
| 700 | 1 | 0 | |a Haruhiko Sugimura |e author |
| 700 | 1 | 0 | |a Kazutaka Ikeda |e author |
| 700 | 1 | 0 | |a Yoshio Goshima |e author |
| 245 | 0 | 0 | |a Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice |
| 260 | |b Elsevier, |c 2020-10-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2020.07.003 | ||
| 520 | |a l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and smoking behaviors revealed that the single-nucleotide polymorphism rs6640499, in the GPR143 gene, was associated with traits of smoking behaviors in Japanese individuals. In Gpr143 gene-deficient mice, nicotine-induced hypolocomotion and rewarding effect were attenuated compared to those in wild-type mice. Our findings suggest the involvement of GPR143 in the smoking behaviors. | ||
| 546 | |a EN | ||
| 690 | |a GPR143 | ||
| 690 | |a Nicotine | ||
| 690 | |a Polymorphism | ||
| 690 | |a Addiction | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 144, Iss 2, Pp 89-93 (2020) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861320300670 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/9fc2bc4cfa004a55ab0bbada4d5a0d21 |z Connect to this object online. |