Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice

• Main Authors: Daiki Masukawa (Author), Daisuke Nishizawa (Author), Kaori Kanai (Author), Satoshi Kitamura (Author), Yuka Kasahara (Author), Tatsuo Hashimoto (Author), Ryo Takahagi (Author), Junko Hasegawa (Author), Kyoko Nakayama (Author), Naomi Sato (Author), Fumihiko Tanioka (Author), Haruhiko Sugimura (Author), Kazutaka Ikeda (Author), Yoshio Goshima (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA. In this study, genetic association studies between GPR143 genetic polymorphisms and...