Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients

• Main Authors: Thuan Duc Lao (Author), Minh Trong Nguyen (Author), Dung Huu Nguyen (Author), Thuy Ai Huyen Le (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.18502/ijph.v50i8.6810; 2251-6085; 2251-6093
• Keywords: Mirn155 microRNA; Nasopharyngeal carcinoma; Vietnamese; Public aspects of medicine; RA1-1270
• Source: Iranian Journal of Public Health, Vol 50, Iss 8 (2021)

Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients. Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR. Results: The frequency of miR-155 detection were 78.33%, 15.0% in NPC and non-cancerous samples (P<0.05), respectively. The miR-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample. Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population.