Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries

• Main Authors: Reza Salehi (Author), Brandon A. Wyse (Author), Meshach Asare-Werehene (Author), Fereshteh Esfandiarinezhad (Author), Atefeh Abedini (Author), Bo Pan (Author), Yoko Urata (Author), Alex Gutsol (Author), Jose L. Vinas (Author), Sahar Jahangiri (Author), Kai Xue (Author), Yunping Xue (Author), Kevin D. Burns (Author), Barbara Vanderhyden (Author), Julang Li (Author), Yutaka Osuga (Author), Dylan Burger (Author), Seang-Lin Tan (Author), Clifford L. Librach (Author), Benjamin K. Tsang (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Polycystic ovarian syndrome (PCOS) is a complex multi-factorial syndrome associated with androgen excess and anovulatory infertility. In the current study, we investigated the role of dihydrotestosterone-induced exosomal miR-379-5p release in determining the destiny of the developing follic...