Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release While Enhancing Galectin-9, TGFβ, and Th1 Polarization

• Main Authors: Saskia A. Overbeek (Author), Atanaska I. Kostadinova (Author), Martine A. Boks (Author), Simone M. Hayen (Author), Wilco de Jager (Author), Belinda van't land (Author), Leon M. Knippels (Author), Johan Garssen (Author), Linette E. M. Willemsen (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS) and CpG-ODN affect intestinal epithelial cells (IEC). Epithelial IL1α may contribute to allergic sensitization via autocrine mediator release affecting dendritic cells (DC). We studied whether IL1α contributes to T...