UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two <i>Achillea</i> Species (<i>A. aleppica</i> and <i>A. santolinoides</i>) from Turkey
In the current study, <i>Achillea santolinoides</i> and <i>Achillea aleppica</i> aeral parts and root were extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were obtained using UHPLC-MS, yielding the identification of hydroxybenzoic and hydrox...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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MDPI AG,
2021-07-01T00:00:00Z.
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| Summary: | In the current study, <i>Achillea santolinoides</i> and <i>Achillea aleppica</i> aeral parts and root were extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were obtained using UHPLC-MS, yielding the identification of hydroxybenzoic and hydroxycinnamic acids, phenolic acid glycosides and sugar esters, acylquinic acids, <i>O</i>-glycosyl flavones and flavonols, and flavonoid aglycons, among others. The antioxidant properties and enzyme inhibitory activities of the extracts were assayed with in vitro tests. The phenolic content of the water extracts was significantly higher as compared to the ethyl acetate and methanol ones. <i>A. aleppica</i> aerial parts methanol extract possessed highest flavonoid content (49.18 mg rutin equivalent/g). Antioxidant properties assessment revealed that the methanol extract of <i>A. santolinoides</i> roots actively scavenged DPPH (54.11 mg TE/g) and ABTS radicals (112.53 mg TE/g) and possessed highest reducing potential (183.55 and 129.92 mg TE/g, for CUPRAC and FRAP, respectively). The ethyl acetate extracts of aerial parts and roots of both species showed highest inhibition against BuCHE (6.07-6.76 mg GALAE/g). The ethyl acetate extract of <i>A.</i><i>santolinoides</i> aerial part showed highest inhibition against tyrosinase (73.00 mg KAE/g). These results showed that the tested <i>Achillea</i> species might represent novel phytotherapeutic avenues for the management of Alzheimer's disease and epidermal hyperpigmentation conditions, which are both associated with oxidative stress. This paper could shed light into future potential industrial applications using the tested <i>Achillea</i> species. |
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| Item Description: | 10.3390/antiox10081180 2076-3921 |