The effect of mutation on neurotoxicity reduction of new chimeric reteplase, a computational study

• Main Authors: Pardis Mohammadi pour (Author), Karim Mahnam (Author), Mahsa Taherzadeh (Author), Shahrzad Ahangarzadeh (Author), Abbas Alibakhshi (Author), Elmira Mohammadi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Excitotoxicity in nerve cells is a type of neurotoxicity in which excessive stimulation of receptors (such as N-methyl-d-aspartate glutamate receptors (NMDAR)) leads to the influx of high-level calcium ions into cells and finally cell damage or death. This complication can oc...