Best <i>Helicobacter pylori</i> Eradication Strategy in the Era of Antibiotic Resistance
Antibiotic resistance is the major reason for <i>Helicobacter pylori</i> treatment failure, and the increasing frequency of antibiotic resistance is a challenge for clinicians. Resistance to clarithromycin and metronidazole is a particular problem. The standard triple therapy (proton pum...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
MDPI AG,
2020-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Antibiotic resistance is the major reason for <i>Helicobacter pylori</i> treatment failure, and the increasing frequency of antibiotic resistance is a challenge for clinicians. Resistance to clarithromycin and metronidazole is a particular problem. The standard triple therapy (proton pump inhibitor, amoxicillin, and clarithromycin) is no longer appropriate as the first-line treatment in most areas. Recent guidelines for the treatment of <i>H. pylori</i> infection recommend a quadruple regimen (bismuth or non-bismuth) as the first-line therapy. This treatment strategy is effective for areas with high resistance to clarithromycin or metronidazole, but the resistance rate inevitably increases as a result of prolonged therapy with multiple antibiotics. Novel potassium-competitive acid blocker-based therapy may be effective, but the data are limited. Tailored therapy based on antimicrobial susceptibility test results is ideal. This review discussed the current important regimens for <i>H. pylori</i> treatment and the optimum <i>H. pylori</i> eradication strategy. |
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| Item Description: | 10.3390/antibiotics9080436 2079-6382 |