Recurrent neutropenia and chronic diarrhea following thymectomy: the good, the bad, and the ugly

Good syndrome (GS) is a rare paraneoplastic syndrome seen before or after diagnosis of thymoma, and its treatment, and is characterized by hypogammaglobulinemia. Rarely, pure white cell aplasia (PWCA) can also be seen which can present as recurrent neutropenia. We describe a 64-year-old man with rec...

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Main Authors: Mosunmoluwa Oyenuga (Author), Safia Shaikh (Author), Benjamin Harris (Author), Jyotsana Sinha (Author), Alexandre Lacasse (Author)
Format: Book
Published: Greater Baltimore Medical Center, 2021-03-01T00:00:00Z.
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100 1 0 |a Mosunmoluwa Oyenuga  |e author 
700 1 0 |a Safia Shaikh  |e author 
700 1 0 |a Benjamin Harris  |e author 
700 1 0 |a Jyotsana Sinha  |e author 
700 1 0 |a Alexandre Lacasse  |e author 
245 0 0 |a Recurrent neutropenia and chronic diarrhea following thymectomy: the good, the bad, and the ugly 
260 |b Greater Baltimore Medical Center,   |c 2021-03-01T00:00:00Z. 
500 |a 2000-9666 
500 |a 10.1080/20009666.2021.1877400 
520 |a Good syndrome (GS) is a rare paraneoplastic syndrome seen before or after diagnosis of thymoma, and its treatment, and is characterized by hypogammaglobulinemia. Rarely, pure white cell aplasia (PWCA) can also be seen which can present as recurrent neutropenia. We describe a 64-year-old man with recurrent sinus infections and previous thymectomy for stage 1 type B2 thymoma presenting with chronic diarrhea and recurrent neutropenia necessitating serial hospitalizations despite repeated antimicrobial treatment. Immunoglobulin levels, including IgM, IgA, IgD, and IgE were undetectable. Flow cytometry also showed absent B cells. Patient was initiated on immunoglobulin replacement therapy with consequent significant clinical improvement. Despite thymectomy, patients can develop thymoma-associated paraneoplastic syndromes, including GS. 
546 |a EN 
690 |a good syndrome 
690 |a thymoma 
690 |a thymectomy 
690 |a hypogammaglobulinemia 
690 |a pure white cell aplasia 
690 |a neutropenia 
690 |a immunodeficiency 
690 |a chronic diarrhea 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 2, Pp 263-265 (2021) 
787 0 |n http://dx.doi.org/10.1080/20009666.2021.1877400 
787 0 |n https://doaj.org/toc/2000-9666 
856 4 1 |u https://doaj.org/article/a09f16f9def749caaea4ddb3408f6bcc  |z Connect to this object online.