Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice

• Main Authors: Liu Yen-Chin (Author), Berta Temugin (Author), Liu Tong (Author), Tan Ping-Heng (Author), Ji Ru-Rong (Author)
• Format: Book
• Published: SAGE Publishing, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Despite decades of intense research efforts, actions of acute opioids are not fully understood. Increasing evidence suggests that in addition to well-documented antinociceptive effects opioids also produce paradoxical hyperalgesic an...