Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

• Main Authors: Michel Barbosa de Araújo (Author), Roberto Carlos Vieira Junior (Author), Leandro Pereira de Moura (Author), Marcelo Costa Junior (Author), Rodrigo Augusto Dalia (Author), Amanda Christine da Silva Sponton (Author), Carla Ribeiro (Author), Maria Alice Rostom de Mello (Author)
• Format: Book
• Published: Universidade Estadual Paulista (UNESP), 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The purpose of this study was to evaluate the effect of creatine supplementation in the diet on indicators of glucose metabolism in skeletal muscle of exercised rats. Forty Wistar adult rats were distributed into four groups for eight weeks: 1) Control: sedentary rats that received balanced diet; 2) Creatine control: sedentary rats that received supplementation of 2% creatine in the balanced diet; 3) Trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received balanced diet; and 4) Supplemented-trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received creatine supplementation (2%) in the balanced diet. The hydric intake increased and the body weight gain decreased in the supplemented-trained group. In the soleus muscle, the glucose oxidation increased in both supplemented groups. The production of lactate and glycemia during glucose tolerance test decreased in the supplemented-trained group. Creatine supplementation in conjunction with exercise training improved muscular glycidic metabolism of rats.

Item Description

1980-6574
10.1590/S1980-65742013000400007