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Mesenchymal Hamartoma With Elevated Alpha-Fetoprotein: A Diagnostic Pitfall

Mesenchymal hamartoma (MH) is a benign liver tumor accounting for 3% to 8% of all liver tumors in children, commonly manifesting before 3 years of life. Distinguishing MH from hepatoblastoma and other liver tumors relies on imaging and alpha-fetoprotein (which is usually within normal range in MH),...

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Main Authors: Amine Naggar MD (Author), Hajar Andour MD (Author), Hamza Bensaghir MD (Author), Badr Kabila MD (Author), Chaimae Ben Driss MD (Author), Soukaina El Aouni MD (Author), Monim Ochan PhD (Author), Mounir Kisra PhD (Author), Najat Lamalmi PhD (Author), Siham El Haddad PhD (Author), Nazik Allali PhD (Author), Latifa Chat PhD (Author)
Format: Book
Published: SAGE Publishing, 2023-08-01T00:00:00Z.
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Summary:Mesenchymal hamartoma (MH) is a benign liver tumor accounting for 3% to 8% of all liver tumors in children, commonly manifesting before 3 years of life. Distinguishing MH from hepatoblastoma and other liver tumors relies on imaging and alpha-fetoprotein (which is usually within normal range in MH), before histologic examination. We report a case of a hepatic MH associated with elevated alpha-fetoprotein, leading to a misdiagnosis of hepatoblastoma and the administration of chemotherapy. We draw the attention to the diagnostic difficulty and pitfalls related to alpha-fetoprotein elevation in the setting of a liver tumor, and we highlight the importance of imaging and histology in establishing the diagnosis.
Item Description:2333-794X
10.1177/2333794X231193560

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