Mechanisms of Resistance To -Lactam Antibiotics in Staphylococcus aureus
S. aureus has shown a great power of adaptation to antimicrobial agents, acquiring, step-by step, resistance to all available antibiotics for treatment of the infections it causes. S. aureus has three major mechanisms of resistance to B-lactam antibiotics: enzyme mediated (penicillinase or B-lactama...
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| Main Authors: | , |
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| Format: | Book |
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales,
2010-08-01T00:00:00Z.
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| Summary: | S. aureus has shown a great power of adaptation to antimicrobial agents, acquiring, step-by step, resistance to all available antibiotics for treatment of the infections it causes. S. aureus has three major mechanisms of resistance to B-lactam antibiotics: enzyme mediated (penicillinase or B-lactamase) by which the antibiotic is inactivated; intrinsic resistance,which is not due to drug inactivation and accounts for methicillin resistance;and modifications of penicillin-binding proteins (PBPs). Additionally, S. aureus can express the tolerance phenomenon, in which there is a dissociation of the inhibitory and killing actions of â-lactam antibiotics. Of these, the most important mechanism is intrinsic resistance, which is probably more complex because several factors can affect its expression. |
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| Item Description: | 0075-5222 2477-9628 |