Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway

• Main Authors: Zhe Wang (Author), Zhida Chen (Author), Xinyi Wang (Author), Yepeng Hu (Author), Jing Kong (Author), Jiabin Lai (Author), Tiekun Li (Author), Bibi Hu (Author), Yikai Zhang (Author), Xianan Zheng (Author), Xiaoxian Liu (Author), Shengyao Wang (Author), Shu Ye (Author), Qiao Zhou (Author), Chao Zheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Low grade of sterile inflammation plays detrimental roles in the progression of diabetic kidney disease (DKD). Sappanone A (SA), a kind of homoisoflavanone isolated from the heartwood of Caesalpinia sappan, exerts anti-inflammatory effects in acute kidney injury. However, whether SA has...