A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone

The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of ne...

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Bibliographic Details
Main Authors: Abu Syed Md. Mosaddek (Author), Md. Mamun Ur Rashid (Author)
Format: Book
Published: Bangladesh Pharmacological Society, 2008-06-01T00:00:00Z.
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Summary:The anti-inflammatory effect of aqueous extract of neem leaf (400 mg/kg body weight) was compared with that of dexamethasone (0.75 mg, intraperitoneally) by administering one hour before the formalin injection and once daily for 7 days in rats. The percentage of inhibition of paw edema in case of neem after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 28%, 40%, 45%, 58% respectively and that in case of dexamethasone after 3 hours, 6 hours, on day 3, on day 7 after formalin injection were 43%, 58%, 61%, 65% respectively. The reduction was statistically significant in each case (p<0.001). The present study suggests that anti-inflammatory effect of neem extract is less than that produced by dexamethasone.
Item Description:1991-007X
1991-0088