Heat pre-treatment can abolish anti-drug antibody interference in ligand binding pharmacokinetic assays
Abstract Anti-drug antibodies (ADAs) can interfere with ligand binding assays (LBAs) by binding to epitopes recognized by the assay antibodies or by preventing assay antibody binding through steric hindrance. This can lead to underestimation of total drug concentration in pharmacokinetic (PK) sample...
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| Main Authors: | , , |
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| Format: | Book |
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SpringerOpen,
2022-04-01T00:00:00Z.
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