Comprehensive Ocular and Systemic Safety Evaluation of Polysialic Acid-Decorated Immune Modulating Therapeutic Nanoparticles (PolySia-NPs) to Support Entry into First-in-Human Clinical Trials

• Hoofdauteurs: Anitha Krishnan (Auteur), David G. Callanan (Auteur), Victor G. Sendra (Auteur), Amit Lad (Auteur), Sunny Christian (Auteur), Ravinder Earla (Auteur), Ali Khanehzar (Auteur), Andrew J. Tolentino (Auteur), Valory Anne Sarmiento Vailoces (Auteur), Michelle K. Greene (Auteur), Christopher J. Scott (Auteur), Derek Y. Kunimoto (Auteur), Tarek S. Hassan (Auteur), Mohamed A. Genead (Auteur), Michael J. Tolentino (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2024-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has been developed to treat geographic atrophy/age-related macular degeneration and other conditions caused by macrophage and complement over-activation. While PolySia-NPs have demonstrated pre-clinical efficacy, this...