LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway
BackgroundCorneal neovascularization (CNV) is a sight-threatening condition that necessitates epigenetic control. The role of lysine-specific demethylase 1 (LSD1) in CNV remains unclear, despite its established significance in tumor angiogenesis regulation.MethodsAn alkali burn-induced CNV mouse mod...
Saved in:
Main Authors: | Qian Deng (Author), Yuelan Gao (Author), Yujin Wang (Author), Jiewen Mao (Author), Yulin Yan (Author), Zixian Yang (Author), Yuyu Cong (Author), Yanning Yang (Author), Shanshan Wan (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2024-07-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
by: Rossella Fioravanti, et al.
Published: (2022) -
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor
by: Chen L, et al.
Published: (2018) -
Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization
by: Dong Liu, et al.
Published: (2019) -
Ferrostatin‐1‐loaded liposome for treatment of corneal alkali burn via targeting ferroptosis
by: Kai Wang, et al.
Published: (2022) -
Natural products as LSD1 inhibitors for cancer therapy
by: Yuan Fang, et al.
Published: (2021)