LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

• Main Authors: Qian Deng (Author), Yuelan Gao (Author), Yujin Wang (Author), Jiewen Mao (Author), Yulin Yan (Author), Zixian Yang (Author), Yuyu Cong (Author), Yanning Yang (Author), Shanshan Wan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundCorneal neovascularization (CNV) is a sight-threatening condition that necessitates epigenetic control. The role of lysine-specific demethylase 1 (LSD1) in CNV remains unclear, despite its established significance in tumor angiogenesis regulation.MethodsAn alkali burn-induced CNV mouse mod...