Between Scylla and Charybdis: thrombosis in children with hemophilia

Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembol...

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Main Authors: Jad El Maamari (Author), Ali Amid (Author), Marie-Claude P (Author), Soumitra Tole (Author)
Format: Book
Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
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100 1 0 |a Jad El Maamari  |e author 
700 1 0 |a Ali Amid  |e author 
700 1 0 |a Marie-Claude P  |e author 
700 1 0 |a Marie-Claude P  |e author 
700 1 0 |a Soumitra Tole  |e author 
700 1 0 |a Soumitra Tole  |e author 
245 0 0 |a Between Scylla and Charybdis: thrombosis in children with hemophilia 
260 |b Frontiers Media S.A.,   |c 2023-05-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2023.1173549 
520 |a Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembolism and thrombotic microangiopathy have been reported as complications. The management of thrombosis in children with hemophilia is particularly challenging given the inherent risk of bleeding. In this paper, we present clinical vignettes to review the literature, highlight challenges, and describe our approach to managing thromboembolism in children with hemophilia. 
546 |a EN 
690 |a hemophilia 
690 |a thrombosis 
690 |a children 
690 |a emicizumab 
690 |a CVAD 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 11 (2023) 
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787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/a234e546cccc454e820a9cd774b34352  |z Connect to this object online.