Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery

• Main Authors: Franziska Mitrach (Author), Maximilian Schmid (Author), Magali Toussaint (Author), Sladjana Dukic-Stefanovic (Author), Winnie Deuther-Conrad (Author), Heike Franke (Author), Alexander Ewe (Author), Achim Aigner (Author), Christian Wölk (Author), Peter Brust (Author), Michael C. Hacker (Author), Michaela Schulz-Siegmund (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., in the brain. RNA interference provides interesting therapeutic options to fight cancer ce...