E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte

• Main Authors: Christine M. Kusminski (Author), Violeta I. Gallardo-Montejano (Author), Zhao V. Wang (Author), Vijay Hegde (Author), Perry E. Bickel (Author), Nikhil V. Dhurandhar (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Purpose: Type 2 diabetes remains a worldwide epidemic with major pathophysiological changes as a result of chronic insulin resistance. Insulin regulates numerous biochemical pathways related to carbohydrate and lipid metabolism. Methods: We have generated a novel mouse model that allows u...