Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

• Main Authors: Shumin Yang (Author), Qiong Lv (Author), Ting Luo (Author), Lulu Liu (Author), Rufei Gao (Author), Shumei Chen (Author), Peng Ye (Author), Qingfeng Cheng (Author), Qifu Li (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective. Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent to improve IR, on PEDF production both in vivo and in vitro. Methods. SD rats were divided into normal co...