Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

• Main Authors: Federico Sizzano (Author), Sebastiano Collino (Author), Ornella Cominetti (Author), Daniela Monti (Author), Paolo Garagnani (Author), Rita Ostan (Author), Chiara Pirazzini (Author), Maria Giulia Bacalini (Author), Daniela Mari (Author), Giuseppe Passarino (Author), Claudio Franceschi (Author), Alessio Palini (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The production of reactive oxygen species (ROS) may promote immunosenescence if not counterbalanced by the antioxidant systems. Cell membranes, proteins, and nucleic acids become the target of ROS and progressively lose their structure and functions. This process could lead to an impairment of the i...