Cover Image

Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations

Efavirenz-based combination antiretroviral-therapy (cART) is the recommended regimen during tuberculosis (TB) therapy. In a multi-national parallel prospective-cohort study, we investigated the impact of population and pharmacogenetic variations for efavirenz pharmacokinetics, auto-induction, and im...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sabina Mugusi (Author), Abiy Habtewold (Author), Eliford Ngaimisi (Author), Wondwossen Amogne (Author), Getnet Yimer (Author), Omary Minzi (Author), Eyasu Makonnen (Author), Christopher Sudfeld (Author), Jürgen Burhenne (Author), Eleni Aklillu (Author)
Format:	Book
Published:	Frontiers Media S.A., 2020-02-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Genetic and non‐genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus‐1‐infected children in Ethiopia
by: Adugna Chala, et al.
Published: (2023)

Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania
by: Selemani Saidi Sungi, et al.
Published: (2018)

Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients
by: Jemal Hussien Ahmed, et al.
Published: (2020)

Adherence to combination antiretroviral therapy among orphaned children in Dar es Salaam, Tanzania
by: Sabina F. Mugusi, et al.
Published: (2019)

Efficacy and safety of praziquantel preventive chemotherapy in Schistosoma mansoni infected school children in Southern Ethiopia: A prospective cohort study
by: Tigist Dires Gebreyesus, et al.
Published: (2023)

CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients
by: Jemal Hussien Ahmed, et al.
Published: (2019)

Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials
by: Gabriel Dawit, et al.
Published: (2021)

Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of <i>Schistosoma mansoni</i> Infection
by: Omary Mashiku Minzi, et al.
Published: (2021)

Reduced efficacy of single-dose albendazole against Ascaris lumbricoides, and Trichuris trichiura, and high reinfection rate after cure among school children in southern Ethiopia: a prospective cohort study
by: Tigist Dires Gebreyesus, et al.
Published: (2024)

Antibacterial Activities of Echinops kebericho Mesfin Tuber Extracts and Isolation of the Most Active Compound, Dehydrocostus Lactone
by: Serawit Deyno, et al.
Published: (2021)

Population pharmacokinetics of ivermectin after mass drug administration in lymphatic filariasis endemic communities of Tanzania
by: Adam M. Fimbo, et al.
Published: (2023)

Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania
by: Rajabu Hussein Mnkugwe, et al.
Published: (2021)

Acute and sub-acute toxicity of Echinops kebericho decoction in rats
by: Serawit Deyno, et al.
Published: (2020)

Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review
by: Dereje Nigussie, et al.
Published: (2021)

In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica
by: Markos Tadele, et al.
Published: (2021)

Antibacterial activity of methanol extracts of the leaves of three medicinal plants against selected bacteria isolated from wounds of lymphoedema patients
by: Dereje Nigussie, et al.
Published: (2021)

Effect of Genetic Variations in Drug-Metabolizing Enzymes and Drug Transporters on the Pharmacokinetics of Rifamycins: A Systematic Review
by: Sileshi T, et al.
Published: (2022)

The Impact of First-Line Anti-Tubercular Drugs’ Pharmacokinetics on Treatment Outcome: A Systematic Review
by: Sileshi T, et al.
Published: (2021)

Antitrypanosomal activity of hydromethanol extract of leaves of Cymbopogon citratus and seeds of Lepidium sativum: in-vivo mice model
by: Ayechew Yetayeh Emiru, et al.
Published: (2021)

Sahara Occidental Conflit oublié, population en mouvement
Published: (2018)

Sahara
by: Buchanan, Angus, 1886-1954; Salvesen, Edward Theodore, Baron Salvesen, 1857-1942 [Author of introduction, etc.]

The Sahara
by: Loti, Pierre, 1850-1923; Lamplough, A. O. (Augustus O.), 1877-1930 [Illustrator]; Laurie, Marjorie [Translator]

Pharmacogenetics in the Brazilian population
by: Guilherme eSuarez-Kurtz
Published: (2010)

In vivo antihypertensive and antidyslipidemic effects of the crude extracts and fractions of Moringa stenopetala (Baker f.) Cufod. leaves in rats.
by: Bekesho eGeleta, et al.
Published: (2016)

Villes du Sahara
by: Olivier Pliez
Published: (2003)

Through Spain to the Sahara
by: Betham-Edwards, Matilda, 1836-1919

A Son of the Sahara
by: Gerard, Louise, 1878-1970

Introducing SAHARA J
Published: (2004)

Chronic (52-week) oral toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar albino rats
by: Abdu Hassen Musa, et al.
Published: (2022)

Evaluation of population‐level pharmacogenetic actionability in Alabama
by: Brittney H. Davis, et al.
Published: (2021)

Botanical features of the Algerian Sahara
by: Cannon, William Austin, 1870-1958

The Horses of the Sahara and the Manners of the Desert
by: Daumas, E.‏ (Eugène), 1803-1871; Hutton, James, 1818-1893 [Translator]

Effect of Improved access to Antiretroviral Therapy on clinical characteristics of patients enrolled in the HIV care and treatment clinic, at Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania
by: Swai Andrew B, et al.
Published: (2010)

Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.
by: Rajabu Hussein Mnkugwe, et al.
Published: (2020)

Across the Sahara Tracks, Trade and Cross-Cultural Exchange in Libya /
Published: (2020)

Across the Sahara Tracks, Trade and Cross-Cultural Exchange in Libya
Published: (2020)

Across the Sahara Tracks, Trade and Cross-Cultural Exchange in Libya
Published: (2020)

Efavirenz in pregnancy
by: Polly Clayden, et al.
Published: (2010)

Prevalence of obesity and associated risk factors among adults in Kinondoni municipal district, Dar es Salaam Tanzania
by: Mugusi Ferdinand M, et al.
Published: (2011)

Pharmacogenetic implications in the management of metabolic diseases in Brazilian populations
by: Rosario Dominguez Crespo Hirata, et al.
Published: (2018)