Sepsis: Changing Definitions, Unchanging Treatment

The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle i...

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Bibliographic Details
Main Authors: Nchafatso Gikenyi Obonyo (Author), Luregn Jan Schlapbach (Author), John Francis Fraser (Author)
Format: Book
Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
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Summary:The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardized criteria for sepsis that can be applied to pediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment strategies to improve clinical outcomes.
Item Description:2296-2360
10.3389/fped.2018.00425