Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatoni...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Taylor & Francis Group,
2020-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were obtained from melatonin administrated RUPP rats Results: Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion: Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring. |
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| Item Description: | 1064-1955 1525-6065 10.1080/10641955.2020.1802595 |