SINTESIS 4-HIDROKSI-3-KLOROBENZALDEHID DARI p-HIDROKSIBENZALDEHID DAN GAS Cl2
Curcumin is a compound which potential to be developed. The curcumin analogues have been synthesized. The compound 3-chloro-4-hydroxybenzaldehyde was used as starting material in the synthesis of curcumin analogues with Cl substituent on the aromatic ring. The compound of 3-chloro-4-hydroxybenzaldeh...
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| Format: | Book |
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Universitas Ahmad Dahlan,
2015-05-01T00:00:00Z.
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| Summary: | Curcumin is a compound which potential to be developed. The curcumin analogues have been synthesized. The compound 3-chloro-4-hydroxybenzaldehyde was used as starting material in the synthesis of curcumin analogues with Cl substituent on the aromatic ring. The compound of 3-chloro-4-hydroxybenzaldehyde were synthesized by chlorination reaction between p-hydroxybenzaldehyde and Cl2 gas. The purity of 3-chloro-4-hydroxybenzaldehyde was determined base on the melting range, thin layer chromatography and LC-MS. The structure identification of the compound was observed done by spectrometry techniques, including mass spectra (ESI-MS), infrared spectra (cm-1, KBr), Nuclear Magnetic resonance proton spectra (δ, ppm, DMSO-d6, 1H-NMR, 500 MHz) and UV-Vis spectra. Chlorination reaction of p-hydroxybenzaldehyde produced yellow crystal of 3-chloro-4-hydroxybenzaldehyde, its melting range is 128.1 to 130.8ºC. The average yield obtained of this reseach is 51.37%. |
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| Item Description: | 10.12928/pharmaciana.v5i1.2967 2088-4559 2477-0256 |