Nanomolar activity of 4-hydrazinylphenyl benzenesulfonate against breast cancer Michigan Cancer Foundation-7 cell lines
Hydrazine is an alkaline reduction compound which is widely used in synthesis. Based on the structure-activity analysis, to elicit antitumor activity, the presence of the N-methyl group is an absolute requirement. The aim of the research is to synthesize a new hydrazine derivate compound that has po...
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| Materiálatiipa: | Girji |
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Wolters Kluwer Medknow Publications,
2022-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a3078bb6a1954204ad9fb0c75a8064aa | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Riska Prasetiawati |e author |
| 700 | 1 | 0 | |a Syahrul Hidayat |e author |
| 700 | 1 | 0 | |a Adel Zamri |e author |
| 700 | 1 | 0 | |a Muchtaridi Muchtaridi |e author |
| 245 | 0 | 0 | |a Nanomolar activity of 4-hydrazinylphenyl benzenesulfonate against breast cancer Michigan Cancer Foundation-7 cell lines |
| 260 | |b Wolters Kluwer Medknow Publications, |c 2022-01-01T00:00:00Z. | ||
| 500 | |a 2231-4040 | ||
| 500 | |a 0976-2094 | ||
| 500 | |a 10.4103/japtr.japtr_435_22 | ||
| 520 | |a Hydrazine is an alkaline reduction compound which is widely used in synthesis. Based on the structure-activity analysis, to elicit antitumor activity, the presence of the N-methyl group is an absolute requirement. The aim of the research is to synthesize a new hydrazine derivate compound that has potency as a novel anti-breast cancer. 4-hydrazinylphenyl benzenesulfonate was synthesized employing reduction and diazotization methods. Structure characterization was carried out using Fourier transform infrared (FTIR), C13-nuclear magnetic resonance (NMR), H1-NMR, and High Resolution Time-of-Flight Mass Spectrometry (HR-TOF-MS). The anti-cancer activity of this compound against breast cancer Michigan Cancer Foundation-7 (MCF-7) cell line was determined using a PrestoBlue viability assay. The new of hydrazine derivative, 4-hydrazinylphenyl benzenesulfonate, has been successfully synthesized. The reduction and diazotization methods have been successfully used in the synthesis of new compound of hydrazine derivatives. Structure characterization of 4-hydrazinylphenyl benzenesulfonate was established using FTIR, C13-NMR, H1-NMR, and HR-TOF-MS. The anti-cancer activity of this compound against breast cancer MCF-7 cell line was determined using a PrestoBlue viability assay with IC50 0.00246 μg/mL or 9.32 nM. In conclusion, 4-hydrazinylphenyl benzenesulfonate was successfully synthesized as a new candidate for anti-breast cancer compound. | ||
| 546 | |a EN | ||
| 690 | |a anti-breast cancer | ||
| 690 | |a hydrazine derivate | ||
| 690 | |a synthesis | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Advanced Pharmaceutical Technology & Research, Vol 13, Iss 4, Pp 322-328 (2022) | |
| 787 | 0 | |n http://www.japtr.org/article.asp?issn=2231-4040;year=2022;volume=13;issue=4;spage=322;epage=328;aulast=Prasetiawati | |
| 787 | 0 | |n https://doaj.org/toc/2231-4040 | |
| 787 | 0 | |n https://doaj.org/toc/0976-2094 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a3078bb6a1954204ad9fb0c75a8064aa |z Connect to this object online. |