Comparison of pregnancy rate following IUI between the use of husband's sperm and donor's sperm in Siriraj Hospital

• Main Authors: Achjima Tankul (Author), Japarath Prechapanich (Author)
• Format: Book
• Published: The Royal Thai College of Obstetricians and Gynaecologists, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objectives: To compare pregnancy rate resulting from IUI between the use of husband's sperm and donor's sperm.Materials and Methods:Data on 306 cycles per groups of IUI using husband's sperm (IUI-H) and IUI using donor's sperm (IUI-D) were collected from couples attending Infertility Unit at Siriraj Hospital. Baseline data, as semen analysis parameters were retrieved. Pregnancy rate was compared between groups.Results: Mean age of the women was younger among IUI-D than IUI-H group (33.6±5.3 vs. 34.4±3.4 years, p=0.025). And their husbands were older among IUI-D than IUI-H group (38.0±8.1 vs. 35.4±3.8 years, p<0.001). Women in IUI-H group were more likely to be nulliparous than IUI-D group (97.1% vs. 92.5%, p=0.011). Anovulation in IUI-D is higher than IUI-H (13.1% vs. 8.5%, p<0.001). Ovulation induction regimen and number of follicles were comparable both groups. IUI-D group were significantly likely to have endometrial thickness ≥ 8 mm (79.7% vs. 65.4%, p<0.001). Post wash semen concentration and progressive sperm motility were significantly higher among IUI-H than IUI-D group (70.8±21.6 vs. 42.5±6.7x 106/mL, p<0.001, and 88.9±5.0 vs. 83.6+8.1%, p<0.001, respectively). Overall pregnancy rate was significantly higher among IUI-D than IUI-H group (9.8% vs. 5.6%, p=0.048). Logistic regression analysis demonstrated that the use of donor's sperm and follicles of ≥2 independently increased pregnancy rate (adjusted OR 2.2, 95%CI 1.2-4.3, p=0.018; and 3.5 95%CI 1.7-6.9, p<0.001).Conclusion: Pregnancy rate was significantly higher among IUI cycle using donor's sperm.

Item Description

https://doi.org/10.14456/tjog.2016.23
0857-6084
0857-6084