Promising immunotherapeutic approaches for primary effusion lymphoma
Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin's lymphoma (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated herpes virus (KSHV) infection. A com...
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Open Exploration Publishing Inc.,
2024-06-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_a30f3c6d737a4fa189c00d3435ce577c | ||
042 | |a dc | ||
100 | 1 | 0 | |a Jutatip Panaampon |e author |
700 | 1 | 0 | |a Seiji Okada |e author |
245 | 0 | 0 | |a Promising immunotherapeutic approaches for primary effusion lymphoma |
260 | |b Open Exploration Publishing Inc., |c 2024-06-01T00:00:00Z. | ||
500 | |a 10.37349/etat.2024.00242 | ||
500 | |a 2692-3114 | ||
520 | |a Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin's lymphoma (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated herpes virus (KSHV) infection. A combination antiretroviral therapy (cART) prolongs the lifespan of AIDS and AIDS-related malignant lymphoma patients, but PEL continues to have a dismal prognosis. PEL showed disappointing outcomes with standard chemotherapy such as CHOP or CHOP-like regimens. A PEL status highlights the urgent need for new therapeutic approaches and treatment strategies and improve clinical outcomes. This review discusses the current knowledge and some recent clinical trials for PEL in the platform of immunotherapy as well as promising future immunotherapeutic approaches for PEL. | ||
546 | |a EN | ||
690 | |a primary effusion lymphoma | ||
690 | |a immunotherapeutic approaches | ||
690 | |a immunotherapy | ||
690 | |a Internal medicine | ||
690 | |a RC31-1245 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 3, Pp 699-713 (2024) | |
787 | 0 | |n https://www.explorationpub.com/Journals/etat/Article/1002242 | |
787 | 0 | |n https://doaj.org/toc/2692-3114 | |
856 | 4 | 1 | |u https://doaj.org/article/a30f3c6d737a4fa189c00d3435ce577c |z Connect to this object online. |