Promising immunotherapeutic approaches for primary effusion lymphoma

Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin's lymphoma (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated herpes virus (KSHV) infection. A com...

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Main Authors: Jutatip Panaampon (Author), Seiji Okada (Author)
Format: Book
Published: Open Exploration Publishing Inc., 2024-06-01T00:00:00Z.
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100 1 0 |a Jutatip Panaampon  |e author 
700 1 0 |a Seiji Okada  |e author 
245 0 0 |a Promising immunotherapeutic approaches for primary effusion lymphoma 
260 |b Open Exploration Publishing Inc.,   |c 2024-06-01T00:00:00Z. 
500 |a 10.37349/etat.2024.00242 
500 |a 2692-3114 
520 |a Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin's lymphoma (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated herpes virus (KSHV) infection. A combination antiretroviral therapy (cART) prolongs the lifespan of AIDS and AIDS-related malignant lymphoma patients, but PEL continues to have a dismal prognosis. PEL showed disappointing outcomes with standard chemotherapy such as CHOP or CHOP-like regimens. A PEL status highlights the urgent need for new therapeutic approaches and treatment strategies and improve clinical outcomes. This review discusses the current knowledge and some recent clinical trials for PEL in the platform of immunotherapy as well as promising future immunotherapeutic approaches for PEL. 
546 |a EN 
690 |a primary effusion lymphoma 
690 |a immunotherapeutic approaches 
690 |a immunotherapy 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 3, Pp 699-713 (2024) 
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787 0 |n https://doaj.org/toc/2692-3114 
856 4 1 |u https://doaj.org/article/a30f3c6d737a4fa189c00d3435ce577c  |z Connect to this object online.