Effects of o,p'-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line

• Автори: Camila Bach (Автор), Claudia Rita Corso (Автор), Alan de Almeida Veiga (Автор), Mariana Martins Paraizo (Автор), Lauro Mera de Souza (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

In South Brazil, the incidence of pediatric adrenocortical carcinoma (ACC) is higher than in other regions and countries worldwide. The ACC treatment includes therapy with mitotane, the only adrenolytic drug approved by the FDA. The mitotane metabolism occurs via two main reactions: the β-hydroxylat...