LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation
Abstract Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC....
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2020-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a374301d0cf445f8b9ff1adf508742e3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kaiying Cui |e author |
| 700 | 1 | 0 | |a Genhai Zhu |e author |
| 245 | 0 | 0 | |a LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation |
| 260 | |b BMC, |c 2020-07-01T00:00:00Z. | ||
| 500 | |a 10.1186/s13048-020-00689-6 | ||
| 500 | |a 1757-2215 | ||
| 520 | |a Abstract Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC. Result We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 in luciferase activity assay interacted with miR-216a, while overexpression of CTBP1-AS2 and miR-216a had no significant effects on the expression of each other. However, increased expression level of PTEN, a target of miR-216a, was observed after CTBP1-AS2 overexpression. Increased proliferation rate of OC cells was observed after the overexpression of miR-216a. CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. Conclusion CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation. | ||
| 546 | |a EN | ||
| 690 | |a CTBP1-AS2 | ||
| 690 | |a Ovarian cancer | ||
| 690 | |a miR-216a | ||
| 690 | |a PTEN | ||
| 690 | |a Proliferation | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-6 (2020) | |
| 787 | 0 | |n http://link.springer.com/article/10.1186/s13048-020-00689-6 | |
| 787 | 0 | |n https://doaj.org/toc/1757-2215 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a374301d0cf445f8b9ff1adf508742e3 |z Connect to this object online. |