Resveratrol Inhibited ADAM10 Mediated CXCL16-Cleavage and T-Cells Recruitment to Pancreatic β-Cells in Type 1 Diabetes Mellitus in Mice

• Main Authors: Mohamed S. Abdel-Bakky (Author), Abdulmajeed Alqasoumi (Author), Waleed M. Altowayan (Author), Elham Amin (Author), Mostafa A. Darwish (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> CXCL16 attracts T-cells to the site of inflammation after cleaving by A Disintegrin and Metalloproteinase (ADAM10). <b>Aim:</b> The current study explored the role of ADAM10/CXCL16/T-cell/NF-κB in the initiation of type 1 diabetes (T1D) with special referen...