Influence of Roll Speed during Roll Compaction and Its Effect on the Prediction of Ribbon Solid Fraction

• Main Authors: Martin Lück (Author), Matthias De Saeger (Author), Peter Kleinebudde (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Influence of the roll speed (<i>RS</i>) during roll compaction on ribbon, granule, tablet properties and its effect on the prediction of the ribbon solid fraction at-gap is often neglected or controversially discussed. The aim of this study was to investigate the effect of the <i>RS</i> systematically. Microcrystalline cellulose (<i>MCC</i>) and lactose were compressed at several maximum roll pressures (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>P</mi><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow></msub></mrow></semantics></math></inline-formula>) and <i>RS</i> combinations using a gap-controlled roll compactor. The ribbon solid fraction after elastic recovery (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><msub><mi>F</mi><mrow><mi>r</mi><mi>i</mi><mi>b</mi><mi>b</mi><mi>o</mi><mi>n</mi></mrow></msub></mrow></semantics></math></inline-formula>), granule size distribution and tabletability of the granules as well as the ribbon solid fraction at-gap <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mfenced><mrow><mi>S</mi><msub><mi>F</mi><mrow><mi>g</mi><mi>a</mi><mi>p</mi></mrow></msub></mrow></mfenced></mrow></semantics></math></inline-formula> were measured. The Midoux number (<i>Mi</i>), derived from the Johanson model, was used to predict the ribbon solid fraction at-gap <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo stretchy="false">(</mo><mi>S</mi><msub><mi>F</mi><mrow><mi>M</mi><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula>). The measured <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><msub><mi>F</mi><mrow><mi>g</mi><mi>a</mi><mi>p</mi></mrow></msub></mrow></semantics></math></inline-formula> and the predicted <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><msub><mi>F</mi><mrow><mi>M</mi><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula> lead to a prediction accuracy (<i>PA</i>) of the Midoux number. The results are highly dependent on the material used and the applied <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>P</mi><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow></msub></mrow></semantics></math></inline-formula>. Higher plasticity of the material leads to a reduction in <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>S</mi><msub><mi>F</mi><mrow><mi>r</mi><mi>i</mi><mi>b</mi><mi>b</mi><mi>o</mi><mi>n</mi></mrow></msub></mrow></semantics></math></inline-formula> and granule size with increasing <i>RS</i>. However, this effect can be overcome or reduced by adjusting <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>P</mi><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow></msub></mrow></semantics></math></inline-formula> above the yield pressure of the used material. These results allow for higher roll speeds as a potential upscaling method in roll compaction. On the other side, the <i>PA</i> of the Midoux number was also reduced with increased <i>RS</i> for MCC and had no effect for lactose. Thus, <i>RS</i> seems to be an important factor in the prediction of roll compaction processes and prediction models should include <i>RS</i> as a parameter to improve their accuracy.

Item Description

10.3390/pharmaceutics14112399
1999-4923