Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes the ABL gene on chromosome 9 with breakpoint clus...
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ziauddin University,
2024-05-01T00:00:00Z.
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| 001 | doaj_a4989d7a1e39405e89738e4ec2d2e611 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Najia Tabassum |e author |
| 700 | 1 | 0 | |a Rubina Ghani |e author |
| 700 | 1 | 0 | |a Mohammad Saboor |e author |
| 700 | 1 | 0 | |a Moinuddin Moinuddin |e author |
| 245 | 0 | 0 | |a Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript |
| 260 | |b ziauddin University, |c 2024-05-01T00:00:00Z. | ||
| 500 | |a 2313-7371 | ||
| 500 | |a 2308-2593 | ||
| 520 | |a Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes the ABL gene on chromosome 9 with breakpoint cluster region (BCR) on chromosome 22 generating BCR-ABL oncogene. All BCR-ABL fusion proteins display activated tyrosine kinase activity. Their different types are associated with different clinical course and prognosis. We report a rare case of e1a3 BCR-ABL transcript. So far only 4 cases in patients with CML have been reported. Key Words: BCR-ABL, e1a3, CML. | ||
| 546 | |a EN | ||
| 690 | |a Biochemistry | ||
| 690 | |a QD415-436 | ||
| 690 | |a Dentistry | ||
| 690 | |a RK1-715 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Medicine (General) | ||
| 690 | |a R5-920 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pakistan Journal of Medicine and Dentistry, Vol 4, Iss 1 (2024) | |
| 787 | 0 | |n https://ojs.zu.edu.pk/pjmd/article/view/2820 | |
| 787 | 0 | |n https://doaj.org/toc/2313-7371 | |
| 787 | 0 | |n https://doaj.org/toc/2308-2593 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a4989d7a1e39405e89738e4ec2d2e611 |z Connect to this object online. |