Cefepime Dosing Requirements in Elderly Patients Attended in the Emergency Rooms

• Main Authors: Jesus Ruiz-Ramos PhD (Author), Sergio Herrera-Mateo PhD (Author), Laia López-Vinardell PhD (Author), Ana Juanes-Borrego PhD (Author), Mireia Puig-Campmany PhD (Author), Maria Antonia Mangues-Bafalluy PhD (Author)
• Format: Book
• Published: SAGE Publishing, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1559-3258; 10.1177/15593258221078393
• Keywords: Therapeutics. Pharmacology; RM1-950
• Source: Dose-Response, Vol 20 (2022)

Objective This study aimed to assess the probability of reaching an adequate pharmacokinetic/pharmacodynamic (pK/pD) index for different cefepime dosages in frail patients with bacteremia treated in the emergency room. Methods Simulation study based on Gram-negative bacterial strains that cause bacteremia. The probability of reaching a time above the minimum inhibitory concentration (MIC) at 50% and 100% dosing intervals (fT > 50 and fT > 80% MIC) was assessed for two different renal clearance intervals. Results One hundred twenty nine strains were collected, the predominant species being Escherichia coli (n = 83 [64.3%]). In patients with a ClCr of 30 mL/min, an fT > 50% MIC was reached in more than 90% of the simulations. However, a dose of at least 1 g every 12 h must be administered to reach an fT > 80% MIC. In patients with a ClCr of 30-60 mL/min, the probability of reaching an fT > 50% MIC was higher than 90% with doses of 1 g every 8 h or more, but this value was not reached in > 90% simulations for any of the doses tested in this study. Conclusions Standard cefepime dosing can reach an adequate PK/PD index in frail patients. Nevertheless, a high dose or extended infusion is necessary to reach an fT > 80% MIC in patients with a ClCr > 60 mL/min.