Antioxidant Activity of Planar Catechin Conjugated with Trolox

Planar catechin (PCat), a natural antioxidant with a fixed 3D catechin structure on a plane, exhibits radical-scavenging activity approximately five times stronger than the conventional catechin. We synthesized a compound, PCat-TrOH, by binding Trolox (TrOH), an α-tocopherol analog, to PCat to enhan...

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Main Authors: Wakana Shimizu (Author), Yoshimi Shoji (Author), Kei Ohkubo (Author), Hiromu Ito (Author), Ikuo Nakanishi (Author), Kiyoshi Fukuhara (Author)
Format: Book
Published: MDPI AG, 2024-09-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_a4acb9e80e524b6483f72df6bd3ea9f2
042 |a dc 
100 1 0 |a Wakana Shimizu  |e author 
700 1 0 |a Yoshimi Shoji  |e author 
700 1 0 |a Kei Ohkubo  |e author 
700 1 0 |a Hiromu Ito  |e author 
700 1 0 |a Ikuo Nakanishi  |e author 
700 1 0 |a Kiyoshi Fukuhara  |e author 
245 0 0 |a Antioxidant Activity of Planar Catechin Conjugated with Trolox 
260 |b MDPI AG,   |c 2024-09-01T00:00:00Z. 
500 |a 10.3390/antiox13101165 
500 |a 2076-3921 
520 |a Planar catechin (PCat), a natural antioxidant with a fixed 3D catechin structure on a plane, exhibits radical-scavenging activity approximately five times stronger than the conventional catechin. We synthesized a compound, PCat-TrOH, by binding Trolox (TrOH), an α-tocopherol analog, to PCat to enhance its antioxidant effect against oxidative stress, such as lipid peroxidation. TrOH shows radical-scavenging activity about 6.5 times greater than PCat, and PCat-TrOH exhibited a similar level of radical-scavenging activity to TrOH. Additionally, PCat-TrOH demonstrated twice the radical-scavenging activity against reactive oxygen species compared to PCat or TrOH. This compound is also expected to exhibit an excellent antioxidant effect against lipid peroxidation caused by radical chain reactions, through interactions with vitamin C, similar to that in the case of α-tocopherol. 
546 |a EN 
690 |a catechin 
690 |a trolox 
690 |a tocopherol 
690 |a antioxidant activity 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 13, Iss 10, p 1165 (2024) 
787 0 |n https://www.mdpi.com/2076-3921/13/10/1165 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/a4acb9e80e524b6483f72df6bd3ea9f2  |z Connect to this object online.