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Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer's Disease

<b>Significance:</b> The majority of the drugs which target membrane-embedded protease γ-secretase show an unusual biphasic activation-inhibition dose-response in cells, model animals, and humans. Semagacestat and avagacestat are two biphasic drugs that can facilitate cognitive decline i...

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Bibliographic Details
Main Authors:	Željko M. Svedružić (Author), Katarina Vrbnjak (Author), Manuel Martinović (Author), Vedran Miletić (Author)
Format:	Book
Published:	MDPI AG, 2021-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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