Study of fabomotizole effect on the behavioral disorders in rat offsprigs exposed to tabaco smoke and ethanol

Assessment of fabomotizole effects on postnatal development of newborn and adult rat offspring after maternal ethanol or cigarette smoke exposure was performed. The experiments were carries out in outbred pregnant rats housed in the vivarium of FSBI "Zakusov Institute of Pharmacology". Eac...

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Bibliographic Details
Main Authors: A. S. Solomina (Author), E. D. Shreder (Author), L. G. Kolik (Author), A. D. Durnev (Author)
Format: Book
Published: LLC "Publisher OKI", 2018-03-01T00:00:00Z.
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001 doaj_a4e64157eb1e44e9abd3b5b2b8bf8761
042 |a dc 
100 1 0 |a A. S. Solomina  |e author 
700 1 0 |a E. D. Shreder  |e author 
700 1 0 |a L. G. Kolik  |e author 
700 1 0 |a A. D. Durnev  |e author 
245 0 0 |a Study of fabomotizole effect on the behavioral disorders in rat offsprigs exposed to tabaco smoke and ethanol 
260 |b LLC "Publisher OKI",   |c 2018-03-01T00:00:00Z. 
500 |a 2587-7836 
500 |a 2686-8830 
500 |a 10.24411/2587-7836-2018-10008. 
520 |a Assessment of fabomotizole effects on postnatal development of newborn and adult rat offspring after maternal ethanol or cigarette smoke exposure was performed. The experiments were carries out in outbred pregnant rats housed in the vivarium of FSBI "Zakusov Institute of Pharmacology". Each group included at least 10 animals. Ethanol (4.3 ml/kg, 40 % vol.) was administered per os from 10 to 19 days of pregnancy; exposure to cigarette smoke from 4 cigarettes with filter (13 mg of tar and 1 mg nicotine) was performed throughout the pregnancy once a day. Fabomotizole (1 and 10 mg/kg, daily) was administered per os in all experiments. The unconditional reflexes formation and muscle strength were evaluated on postnatal day 5. The same animals were examined in the tests «T-shaped maze» and «extrapolation disposal» to assess cognitive functions after postnatal day 60. These studies demonstrated the ability of fabomotizole to prevent or reduce postnatal abnormalities of rats exposed to ethanol or tobacco smoke in utero. The results show the potential opportunity of using fabomotizole for prevention of delay physical development, learning and memory. 
546 |a RU 
690 |a этанол 
690 |a табачный дым 
690 |a фабомотизол 
690 |a постнатальное развитие 
690 |a крысы 
690 |a ethanol 
690 |a tobacco smoke 
690 |a fabomotizole 
690 |a postnatal development 
690 |a rats 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 3-11 (2018) 
787 0 |n https://www.pharmacokinetica.ru/jour/article/view/54 
787 0 |n https://doaj.org/toc/2587-7836 
787 0 |n https://doaj.org/toc/2686-8830 
856 4 1 |u https://doaj.org/article/a4e64157eb1e44e9abd3b5b2b8bf8761  |z Connect to this object online.